Adverse events observed in association with the use of clozaril in clinical trials at an incidence of greater than 5 were central nervous system complaints, including drowsiness sedation, dizziness vertigo, headache and tremor; autonomic nervous system complaints, including salivation, sweating, dry mouth and visual disturbances; cardiovascular findings, including tachycardia, hypotension and syncope; and gastrointestinal complaints, including constipation and nausea; and fever.
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Clozapine can also cause seizuresespecially in higher dosesLet your doctor or pharmacist know if you have ever had seizuresWhile taking this medicationavoid driving or other activities during which a sudden loss of consciousness could be dangerouse.goperating heavy machineryswimming
Cases have been reported of an interaction between citalopram and clozapinewhich may increase the risk of adverse events associated with clozapineThe nature of this interaction has not been fully elucidated.
The Clozaril Patient Monitoring Service provides for the centralised monitoring of leucocyte and neutrophil counts which is a mandatory requirement for all patients in the UK who are treated with ClozarilThe use of Clozaril is restricted to patients who are registered with the Clozaril Patient Monitoring ServiceIn addition to registering their patientsprescribing physicians must register themselves and a nominated pharmacist with the Clozaril Patient Monitoring ServiceAll Clozaril-treated patients must be under the supervision of an appropriate specialist and supply of Clozaril is restricted to hospital and retail pharmacies registered with the Clozaril Patient Monitoring ServiceClozaril is not sold toor distributed through wholesalers.
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